Introduction From this empirical paper, it showed that students suffered from stress and mental health problem are gradually increasing in this few years especially of Iranian university students. To prevent the increasing of students facing this issue, this article will help students to learned about stress management. The purpose of this study is to assess the influenced of multiple stress management intervention (MSMI) on academic performance and mental health among university students. Literature review First, focused on emotional and problem stress management can decrease entire worker stress. Improve of academic result and mental wellbeing in order to achieve stress management intervention among high school students in UK. The result showed that the mental ill and anxiety scores are decrease. Stress management training can decrease the passive coping mechanism of college students. Besides, coping therapy and relaxation training effected in changing personality attributes, but it was more impact on reducing depression for the depressive students. Next, stress management based on social marketing evaluation and response tool was very effective for decrease stress and helpful on mental health.